Ficus carica Linn. (Moraceae) commonly known as edible fig has been found to be associated with the several therapeutic properties. The current study used Ficus carica as an ameliorating agent against nephrotoxic effects of potassium dichromate. Potassium dichromate (K2Cr2O7) is a soluble hexavalent chromium compound that is used extensively in several industries. The rats were given pre-treatment of Ficus carica orally at a dose of (100 and 200 mg/kg body weight) for five consecutive days. Potassium dichromate 20 mg/kg b.wt was used as renal toxicant and injected subcutaneously in the neck region. The protective effects of Ficus carica on potassium dichromate induced nephrotoxicity was investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum kidney toxicity markers and by histopathological examination of kidney. Ficus carica pre-treatment prevented deteriorative effects induced by potassium dichromate through a protective mechanism that involved reduction of increased oxidative stress and also by restoration of histopathological changes produced by the administration potassium dichromate.
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